Dog Spinal Injury Steroids - Discussing MPSS And PEG
Intervertebral disc herniation is one of the most common causes of spinal cord damage in dogs (IVDH). In these situations, compression and contusion together cause spinal cord injury.
One aspect of the injury is successfully relieved by surgical decompression, but medical care for the cumulative injury is still problematic.
COPYRIGHT_SPINE: Published on https://spinal-injury.net/dog-spinal-injury-steroids/ by Dr. Bill Butcher on 2022-09-28T04:10:10.274Z
Methylprednisolone sodium succinate (MPSS) is known to work well to stop lipid peroxidation and stop free radicals from being made.
In the National Acute Spinal Cord Injury Studies, or NASCIS trials it was found that starting treatment within 8 hours of the damage was a little bit better.
Even though the results of these trials were initially promising, they are still being debated, and MPSS has not been accepted as a standard of care in human medicine.
Also praised for its capacity to fuse cell membranes, polyethylene glycol (PEG) has improved outcomes in experimental models of spinal cord injury.
In a clinical trial, PEG was examined in dogs who had IVDH-induced paralysis with absent pain sensibility, the most severe degree of injury.
The results for the dogs in this study were similar to what was found in previous retrospective studies that only used surgery, and they were better than the results for historical controls.
How to handle and care for a dog with IVDD. How to carry, pick up and move a painful dog.
There are several different dosing regimes for MPSS and PEG, both of which are frequently used in veterinary medicine to treat spinal cord injuries. Unfortunately, there are distinctly divergent views on when to administer these medications.
Many neurologists and neurosurgeons, including those in some hospital's neurology and neurosurgery departments, do not employ these medications to treat acute spinal cord injury caused by IVDH.
The main reason why they aren't used is that no placebo-controlled, randomized, blinded trials have ever been done on dogs. This means that no one knows how effective or safe they are.
Corticosteroids work better than NSAIDs for spinal analgesia. NSAIDs don't work when there is "chronic, severe compression of the spinal cord or nerves."
Yes. If your dog's mild to severe IVDD injury is discovered early, your veterinarian may attempt to treat it with steroids and anti-inflammatory drugs (to help reduce pain and swelling) along with strict crate rest for around 4 to 6 weeks.
Dogs with very severe spinal injuries may require surgery. Your vet may need to fuse vertebrae together, pin vertebral bone fragments back into place, or remove part or all of a ruptured disk to take pressure off the nerves in your spine.
Since spinal cord tissue does not efficiently heal, the effects of an injury may be catastrophic. If the spinal cord is only partially (incompletely) damaged, dogs can make a full recovery because the remaining nerves can take over the function of the lost ones.
The North Carolina State University College of Veterinary Medicine's Dr. Natasha Olby oversaw a multicenter clinical trial to attempt to ascertain whether these dog spinal injury steroids were of any use.
They thought that dogs with a condition called acute thoracolumbar intervertebral disk herniation (TL-IVDH), which causes serious damage to the spinal cord, would do better if polyethylene glycol (PEG) was used instead of MPSS.
The goal of this blinded, randomized, placebo-controlled clinical trial was to find out if PEG and MPSS are safe and effective when used with decompressive surgery.